A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice

• Main Authors: Adam M. Passman (Author), Robyn P. Strauss (Author), Sarah B. McSpadden (Author), Megan L. Finch-Edmondson (Author), Ken H. Woo (Author), Luke A. Diepeveen (Author), Roslyn London (Author), Bernard A. Callus (Author), George C. Yeoh (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing studies show that LPCs differentiate into function...