Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs To <i>Leishmania infantum</i>-Infected Macrophages

• Main Authors: Laura I. Vossen (Author), Bárbara Domínguez-Asenjo (Author), Camino Gutiérrez-Corbo (Author), M. Yolanda Pérez-Pertejo (Author), Rafael Balaña-Fouce (Author), Rosa María Reguera (Author), Marcelo Calderón (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages are hosts for intracellular pathogens involved in numerous diseases including leishmaniasis. They express surface receptors that may be exploited for specific drug-targeting. Recently, we developed a PEGylated dendritic polyglycerol-based conjugate (PG-PEG) that colocalizes with intracel...