Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels

• Egile Nagusiak: Kazuho Sakamoto (Egilea), Yoshiaki Suzuki (Egilea), Hisao Yamamura (Egilea), Susumu Ohya (Egilea), Katsuhiko Muraki (Egilea), Yuji Imaizumi (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2017-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Voltage-gated K+ (KV) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in many types of diseases. Pimaric acid (PiMA) is a unique opener of large conductance Ca2+-activated K+ channel. Here, we report that PiMA modulat...