Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels

• Main Authors: Kazuho Sakamoto (Author), Yoshiaki Suzuki (Author), Hisao Yamamura (Author), Susumu Ohya (Author), Katsuhiko Muraki (Author), Yuji Imaizumi (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated K+ (KV) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in many types of diseases. Pimaric acid (PiMA) is a unique opener of large conductance Ca2+-activated K+ channel. Here, we report that PiMA modulat...