A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors

• Main Authors: Yumei Liao (Author), Xiaoji Zhuang (Author), Xiaojie Huang (Author), Yinghui Peng (Author), Xuanyue Ma (Author), Zhi-Xing Huang (Author), Feng Liu (Author), Junyu Xu (Author), Ying Wang (Author), Wei-Min Chen (Author), Wen-Cai Ye (Author), Lei Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developing therapeutic approaches that target neuronal differentiation will be greatly beneficial for the regeneration of neurons and synaptic networks in neurological diseases. Protein synthesis (mRNA translation) has recently been shown to regulate neurogenesis of neural stem/progenitor cells (NSP...