Oleic Acid Induces Lung Injury in Mice through Activation of the ERK Pathway

• Main Authors: Cassiano Felippe Gonçalves- (Author), Adriana Ribeiro Silva (Author), Patrícia Burth (Author), Isabel Matos Medeiros de Moraes (Author), Flora Magno de Jesus Oliveira (Author), Mauricio Younes-Ibrahim (Author), Maria da Conceição Batista dos Santos (Author), Heloísa D'Ávila (Author), Patrícia Torres Bozza (Author), Hugo Caire de Castro Faria Neto (Author), Mauro Velho de Castro Faria (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oleic acid (OA) can induce acute lung injury in experimental models. In the present work, we used intratracheal OA injection to show augmented oedema formation, cell migration and activation, lipid mediator, and cytokine productions in the bronchoalveolar fluids of Swiss Webster mice. We also demons...