NS4/5 mutations enhance flavivirus Bamaga virus infectivity and pathogenicity in vitro and in vivo.

• Main Authors: Agathe M G Colmant (Author), Helle Bielefeldt-Ohmann (Author), Laura J Vet (Author), Caitlin A O'Brien (Author), Richard A Bowen (Author), Airn E Hartwig (Author), Steven Davis (Author), Thisun B H Piyasena (Author), Gervais Habarugira (Author), Jessica J Harrison (Author), Jody Hobson-Peters (Author), Roy A Hall (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flaviviruses such as yellow fever, dengue or Zika viruses are responsible for significant human and veterinary diseases worldwide. These viruses contain an RNA genome, prone to mutations, which enhances their potential to emerge as pathogens. Bamaga virus (BgV) is a mosquito-borne flavivirus in the...