Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity

• Main Authors: Joel F. G. Cohen-Solal (Author), Lydie Cassard (Author), Emilie M. Fournier (Author), Shannon M. Loncar (Author), Wolf Herman Fridman (Author), Catherine Sautès-Fridman (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our research, inspired by the pioneering works of Isaac Witz in the 1980s, established that 40% of human metastatic melanomas express ectopically inhibitory Fc gamma receptors (Fc𝛾RIIB), while they are detected on less than 5% of primary cutaneous melanoma and not on melanocytes. We demonstrated tha...