Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

• Main Authors: Jie Li (Author), Xin Li (Author), Yu-Shan Ren (Author), Yuan-Yuan Lv (Author), Jun-Sheng Zhang (Author), Xiao-Li Xu (Author), Xian-Zhen Wang (Author), Jing-Chun Yao (Author), Gui-Min Zhang (Author), Zhong Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated. The purpose of this work was to identify the pharmacokinetic properties of AG via va...