Proton Dependent Inhibition of the Cardiac Sodium Channel Nav1.5 by Ranolazine
Ranolazine is clinically approved for treatment of angina pectoris and is a potential candidate for antiarrhythmic, antiepileptic and analgesic applications. These therapeutic effects of ranolazine hinge on its ability to inhibit persistent or late Na+ currents in a variety of voltage-gated sodium c...
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Frontiers Media S.A.,
2013-06-01T00:00:00Z.
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