Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers

• Main Authors: Mohammad Al‐Mahdi Al‐Karagholi (Author), Jakob Møller Hansen (Author), Dalia Abou‐Kassem (Author), Anna Koldbro Hansted (Author), Kumari Ubhayasekera (Author), Jonas Bergquist (Author), László Vécsei (Author), Inger Jansen‐Olesen (Author), Messoud Ashina (Author)
• Format: Book
• Published: Wiley, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in the pathway, emerges to be a prodrug targeti...