Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation

• Główni autorzy: Xi Jin (Autor), Victor Ng (Autor), Meiling Zhao (Autor), Lu Liu (Autor), Tomoyasu Higashimoto (Autor), Zheng Hong Lee (Autor), Jooho Chung (Autor), Victor Chen (Autor), Gina Ney (Autor), Malathi Kandarpa (Autor), Moshe Talpaz (Autor), Qing Li (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2022-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-RasG12D activates Stat5 to dysregulate stem cell function. However, the underlying mec...