Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation

• मुख्य लेखकों: Xi Jin (लेखक), Victor Ng (लेखक), Meiling Zhao (लेखक), Lu Liu (लेखक), Tomoyasu Higashimoto (लेखक), Zheng Hong Lee (लेखक), Jooho Chung (लेखक), Victor Chen (लेखक), Gina Ney (लेखक), Malathi Kandarpa (लेखक), Moshe Talpaz (लेखक), Qing Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2022-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-RasG12D activates Stat5 to dysregulate stem cell function. However, the underlying mec...