Substantial Effect of Efavirenz Monotherapy on Bilirubin Levels in Healthy Volunteers

• Váldodahkkit: Ingrid F. Metzger, PhD (Dahkki), Troy C. Quigg, MD (Dahkki), Noam Epstein (Dahkki), Abdulateef O. Aregbe, MD (Dahkki), Nancy Thong (Dahkki), John T. Callaghan, MD, PhD (Dahkki), David A. Flockhart, MD, PhD (Dahkki), Anne T. Nguyen (Dahkki), Colleen K. Stevens (Dahkki), Samir K. Gupta (Dahkki), Zeruesenay Desta, PhD (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2014-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism, efavirenz-based HIV therapy affects the dispositi...