Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Main Authors: Rocío Gambaro (Author), Ignacio Rivero Berti (Author), María José Limeres (Author), Cristián Huck-Iriart (Author), Malin Svensson (Author), Silvia Fraude (Author), Leah Pretsch (Author), Shutian Si (Author), Ingo Lieberwirth (Author), Stephan Gehring (Author), Maximiliano Cacicedo (Author), Germán Abel Islan (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...