Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Autori principali: Rocío Gambaro (Autore), Ignacio Rivero Berti (Autore), María José Limeres (Autore), Cristián Huck-Iriart (Autore), Malin Svensson (Autore), Silvia Fraude (Autore), Leah Pretsch (Autore), Shutian Si (Autore), Ingo Lieberwirth (Autore), Stephan Gehring (Autore), Maximiliano Cacicedo (Autore), Germán Abel Islan (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...