Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Үндсэн зохиолчид: Rocío Gambaro (Зохиогч), Ignacio Rivero Berti (Зохиогч), María José Limeres (Зохиогч), Cristián Huck-Iriart (Зохиогч), Malin Svensson (Зохиогч), Silvia Fraude (Зохиогч), Leah Pretsch (Зохиогч), Shutian Si (Зохиогч), Ingo Lieberwirth (Зохиогч), Stephan Gehring (Зохиогч), Maximiliano Cacicedo (Зохиогч), Germán Abel Islan (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2024-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...