Optimizing mRNA-Loaded Lipid Nanoparticles as a Potential Tool for Protein-Replacement Therapy

• Váldodahkkit: Rocío Gambaro (Dahkki), Ignacio Rivero Berti (Dahkki), María José Limeres (Dahkki), Cristián Huck-Iriart (Dahkki), Malin Svensson (Dahkki), Silvia Fraude (Dahkki), Leah Pretsch (Dahkki), Shutian Si (Dahkki), Ingo Lieberwirth (Dahkki), Stephan Gehring (Dahkki), Maximiliano Cacicedo (Dahkki), Germán Abel Islan (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2024-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Lipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0...