Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-<i>f</i>]quinoline Derivatives

• Main Authors: Chhabi Lal Chaudhary (Author), Seungyun Ko (Author), Chaerim Lee (Author), Yerin Kim (Author), Chanhyun Jung (Author), Soonsil Hyun (Author), Youngjoo Kwon (Author), Jong-Soon Kang (Author), Jae-Kyung Jung (Author), Heesoon Lee (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the several targets of cancer treatment, inhibition of DNA topoisomerase activity is one of the well-known focuses in cancer chemotherapy. Here, we describe the design and synthesis of a novel series of pyrazolo[4,3-<i>f</i>]quinolines with potential anticancer/topoisomerase inhibit...