Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

• Автори: Kathryn H. Ching (Автор), Kimberley Berg (Автор), Kevin Reynolds (Автор), Darlene Pedersen (Автор), Alba Macias (Автор), Yasmina N. Abdiche (Автор), William D. Harriman (Автор), Philip A. Leighton (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the same for both arms of the antibody. Here, we int...