Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

• Auteurs principaux: Kathryn H. Ching (Auteur), Kimberley Berg (Auteur), Kevin Reynolds (Auteur), Darlene Pedersen (Auteur), Alba Macias (Auteur), Yasmina N. Abdiche (Auteur), William D. Harriman (Auteur), Philip A. Leighton (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the same for both arms of the antibody. Here, we int...