Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

• Main Authors: Kathryn H. Ching (Author), Kimberley Berg (Author), Kevin Reynolds (Author), Darlene Pedersen (Author), Alba Macias (Author), Yasmina N. Abdiche (Author), William D. Harriman (Author), Philip A. Leighton (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the same for both arms of the antibody. Here, we int...