The novel TFEB agonist desloratadine ameliorates hepatic steatosis by activating the autophagy-lysosome pathway

• Main Authors: Jieru Lin (Author), Chunhuan Huang (Author), Jingye Zhao (Author), Lu Li (Author), Zhenwei Wu (Author), Tingyu Zhang (Author), Yuyin Li (Author), Wei Li (Author), Baoqiang Guo (Author), Zhenxing Liu (Author), Aipo Diao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The autophagy-lysosome pathway plays an essential role in promoting lipid catabolism and preventing hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). Transcription factor EB (TFEB) enhances the autophagy-lysosome pathway by regulating the expression of genes related to autophagy and ly...