Opioid toxicity due to CNS depressant polypharmacy: A case report

• Main Authors: Christine Lee (Author), Annabelle Wanson, MD, FRCPC (Author), Sarah Frangou, BSc, MD (Author), David Chong, BSc, MSc, BMBS (Author), Katelyn Halpape, BSP, ACPR, PharmD, BCPP (Author)
• Format: Book
• Published: American Association of Psychiatric Pharmacists, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The interaction between methadone and central nervous system depressants can cause serious adverse effects, including profound sedation, respiratory depression, coma, and death. This poses a challenge in the treatment of patients with concurrent psychiatric and substance use disorders as the combine...