C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3.

• Main Authors: Yun Wu (Author), Xinyu Yang (Author), Zhicheng Yao (Author), Xinhuai Dong (Author), Danrui Zhang (Author), Yiwen Hu (Author), Shihao Zhang (Author), Jiajie Lin (Author), Jiahui Chen (Author), Shu An (Author), Hengming Ye (Author), Shuqing Zhang (Author), Ziying Qiu (Author), Zhenjian He (Author), Mingxing Huang (Author), Guohong Wei (Author), Xun Zhu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rapidly emerging human health crisis associated with the Zika virus (ZIKV) epidemic and its link to severe complications highlights the growing need to identify the mechanisms by which ZIKV accesses hosts. Interferon response protects host cells against viral infection, while the cellular factor...