Monoterpenoids Induce Agonist-Specific Desensitization of Transient Receptor Potential Vanilloid-3 (TRPV3) ion Channels

• Main Authors: Muhammad Azhar Sherkheli (Author), Heike Benecke (Author), Julia Franca Doerner (Author), Olaf Kletke (Author), A. K. Vogt-Eisele (Author), Guenter Gisselmann (Author), Hanns Hatt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2009-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and in a variety of neural cells. It is activated by warmth as well as monoterpenoids including camphor, menthol, dihydrocarveol and 1,8-cineol. TRPV3 is described as a putative nocicep...