Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• المؤلفون الرئيسيون: Fatima Amin Adamude (مؤلف), Ikenna Nnamdi Ezeaku (مؤلف), Abraham Ehinomhen Ubhenin (مؤلف), Ifeanyi Peter Onyeka (مؤلف), Ahmad Adamu Ambi (مؤلف), Ikechukwu Robert Uroko (مؤلف), Emeka John Dingwoke (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...