Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Egile Nagusiak: Fatima Amin Adamude (Egilea), Ikenna Nnamdi Ezeaku (Egilea), Abraham Ehinomhen Ubhenin (Egilea), Ifeanyi Peter Onyeka (Egilea), Ahmad Adamu Ambi (Egilea), Ikechukwu Robert Uroko (Egilea), Emeka John Dingwoke (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...