Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Auteurs principaux: Fatima Amin Adamude (Auteur), Ikenna Nnamdi Ezeaku (Auteur), Abraham Ehinomhen Ubhenin (Auteur), Ifeanyi Peter Onyeka (Auteur), Ahmad Adamu Ambi (Auteur), Ikechukwu Robert Uroko (Auteur), Emeka John Dingwoke (Auteur)
• Format: Livre
• Publié: Elsevier, 2022-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...