Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• मुख्य लेखकों: Fatima Amin Adamude (लेखक), Ikenna Nnamdi Ezeaku (लेखक), Abraham Ehinomhen Ubhenin (लेखक), Ifeanyi Peter Onyeka (लेखक), Ahmad Adamu Ambi (लेखक), Ikechukwu Robert Uroko (लेखक), Emeka John Dingwoke (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...