Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Үндсэн зохиолчид: Fatima Amin Adamude (Зохиогч), Ikenna Nnamdi Ezeaku (Зохиогч), Abraham Ehinomhen Ubhenin (Зохиогч), Ifeanyi Peter Onyeka (Зохиогч), Ahmad Adamu Ambi (Зохиогч), Ikechukwu Robert Uroko (Зохиогч), Emeka John Dingwoke (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2022-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...