Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Главные авторы: Fatima Amin Adamude (Автор), Ikenna Nnamdi Ezeaku (Автор), Abraham Ehinomhen Ubhenin (Автор), Ifeanyi Peter Onyeka (Автор), Ahmad Adamu Ambi (Автор), Ikechukwu Robert Uroko (Автор), Emeka John Dingwoke (Автор)
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• Опубликовано: Elsevier, 2022-08-01T00:00:00Z.
• Предметы: article
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Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...