Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

• Main Authors: Fatima Amin Adamude (Author), Ikenna Nnamdi Ezeaku (Author), Abraham Ehinomhen Ubhenin (Author), Ifeanyi Peter Onyeka (Author), Ahmad Adamu Ambi (Author), Ikechukwu Robert Uroko (Author), Emeka John Dingwoke (Author)
• 格式: 图书
• 出版: Elsevier, 2022-08-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...