The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

• Päätekijät: Rebecca R. Florke Gee (Tekijä), Andrew D. Huber (Tekijä), Jing Wu (Tekijä), Richa Bajpai (Tekijä), Allister J. Loughran (Tekijä), Shondra M. Pruett-Miller (Tekijä), Taosheng Chen (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, less is known about the regulation of PXR protein le...