The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

• मुख्य लेखकों: Rebecca R. Florke Gee (लेखक), Andrew D. Huber (लेखक), Jing Wu (लेखक), Richa Bajpai (लेखक), Allister J. Loughran (लेखक), Shondra M. Pruett-Miller (लेखक), Taosheng Chen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, less is known about the regulation of PXR protein le...