The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

• Main Authors: Rebecca R. Florke Gee (Author), Andrew D. Huber (Author), Jing Wu (Author), Richa Bajpai (Author), Allister J. Loughran (Author), Shondra M. Pruett-Miller (Author), Taosheng Chen (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, less is known about the regulation of PXR protein le...