Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

• Автори: Michele Schlich (Автор), Roberto Palomba (Автор), Gabriella Costabile (Автор), Shoshy Mizrahy (Автор), Martina Pannuzzo (Автор), Dan Peer (Автор), Paolo Decuzzi (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2021-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches to the FDA approval of patisiran in 2...