Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

• Asıl Yazarlar: Michele Schlich (Yazar), Roberto Palomba (Yazar), Gabriella Costabile (Yazar), Shoshy Mizrahy (Yazar), Martina Pannuzzo (Yazar), Dan Peer (Yazar), Paolo Decuzzi (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2021-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches to the FDA approval of patisiran in 2...