Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

• Main Authors: Khalid Alyodawi (Author), Wilbert P. Vermeij (Author), Saleh Omairi (Author), Oliver Kretz (Author), Mark Hopkinson (Author), Francesca Solagna (Author), Barbara Joch (Author), Renata M.C. Brandt (Author), Sander Barnhoorn (Author), Nicole vanVliet (Author), Yanto Ridwan (Author), Jeroen Essers (Author), Robert Mitchell (Author), Taryn Morash (Author), Arja Pasternack (Author), Olli Ritvos (Author), Antonios Matsakas (Author), Henry Collins‐Hooper (Author), Tobias B. Huber (Author), Jan H.J. Hoeijmakers (Author), Ketan Patel (Author)
• Format: Book
• Published: Wiley, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background One of the principles underpinning our understanding of ageing is that DNA damage induces a stress response that shifts cellular resources from growth towards maintenance. A contrasting and seemingly irreconcilable view is that prompting growth of, for example, skeletal muscle co...