Pamoic acid is an inhibitor of HMGB1·CXCL12 elicited chemotaxis and reduces inflammation in murine models of Pseudomonas aeruginosa pneumonia

• Main Authors: Federica De Leo (Author), Alice Rossi (Author), Francesco De Marchis (Author), Cristina Cigana (Author), Medede Melessike (Author), Giacomo Quilici (Author), Ida De Fino (Author), Malisa Vittoria Mantonico (Author), Chantal Fabris (Author), Alessandra Bragonzi (Author), Marco Emilio Bianchi (Author), Giovanna Musco (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that once released in the extracellular space acts as a Damage Associated Molecular Pattern and promotes inflammation. HMGB1 is significantly elevated during Pseudomonas aeruginosa infections and has a cli...