Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

• Hoofdauteurs: Anna Durinova (Auteur), Lucie Smutna (Auteur), Pavel Barta (Auteur), Rajamanikkam Kamaraj (Auteur), Tomas Smutny (Auteur), Bernhard Schmierer (Auteur), Petr Pavek (Auteur), Frantisek Trejtnar (Auteur)
• Formaat: Boek
• Gepubliceerd in: SpringerOpen, 2024-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Megalin (LRP2 receptor) mediates the endocytosis of radiolabeled peptides into proximal tubular kidney cells, which may cause nephrotoxicity due to the accumulation of a radioactive tracer. The study aimed to develop a cellular model of human kidney HK2 cells with LRP2 knockout (...