Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

• मुख्य लेखकों: Anna Durinova (लेखक), Lucie Smutna (लेखक), Pavel Barta (लेखक), Rajamanikkam Kamaraj (लेखक), Tomas Smutny (लेखक), Bernhard Schmierer (लेखक), Petr Pavek (लेखक), Frantisek Trejtnar (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SpringerOpen, 2024-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Megalin (LRP2 receptor) mediates the endocytosis of radiolabeled peptides into proximal tubular kidney cells, which may cause nephrotoxicity due to the accumulation of a radioactive tracer. The study aimed to develop a cellular model of human kidney HK2 cells with LRP2 knockout (...