Improving the Solubilization and Bioavailability of Arbidol Hydrochloride by the Preparation of Binary and Ternary β-Cyclodextrin Complexes with Poloxamer 188

• Main Authors: Md. Khalid Anwer (Author), Muzaffar Iqbal (Author), Mohammad Muqtader Ahmed (Author), Mohammed F. Aldawsari (Author), Mohd Nazam Ansari (Author), Essam Ezzeldin (Author), Nasr Y. Khalil (Author), Raisuddin Ali (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current study, the effect of poloxamer 188 on the complexation efficiency and dissolution of arbidol hydrochloride (ADL), a broad-spectrum antiviral agent, with β-cyclodextrin (β-CD) was investigated. Phase solubility studies confirmed a stoichiometry of a 1:1 ratio for both ADL:β-CD and ADL/...