HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

• Главные авторы: Ji-Yon Kim (Автор), So-Youn Woo (Автор), Young Bin Hong (Автор), Heesun Choi (Автор), Jisoo Kim (Автор), Hyunjung Choi (Автор), Inhee Mook-Jung (Автор), Nina Ha (Автор), Jangbeen Kyung (Автор), Soo Kyung Koo (Автор), Sung-Chul Jung (Автор), Byung-Ok Choi (Автор)
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• Опубликовано: Hindawi Limited, 2016-01-01T00:00:00Z.
• Предметы: article
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The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the potential therapeutic effect o...