HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

• Hoofdauteurs: Ji-Yon Kim (Auteur), So-Youn Woo (Auteur), Young Bin Hong (Auteur), Heesun Choi (Auteur), Jisoo Kim (Auteur), Hyunjung Choi (Auteur), Inhee Mook-Jung (Auteur), Nina Ha (Auteur), Jangbeen Kyung (Auteur), Soo Kyung Koo (Auteur), Sung-Chul Jung (Auteur), Byung-Ok Choi (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2016-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the potential therapeutic effect o...