Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats

• Main Authors: Yuansheng Liu (Author), Qian Zhang (Author), Lei Yang (Author), Wencong Tian (Author), Yinan Yang (Author), Yuhang Xie (Author), Jing Li (Author), Liang Yang (Author), Yang Gao (Author), Yang Xu (Author), Jie Liu (Author), Yachen Wang (Author), Jie Yan (Author), Guoxun Li (Author), Yanna Shen (Author), Zhi Qi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coronary artery disease (CAD) and cardiac hypertrophy (CH) are two main causes of ischemic heart disease. Acute CAD may lead to left ventricular hypertrophy (LVH). Long-term and sustained CH is harmful and can gradually develop into cardiac insufficiency and heart failure. It is known that metformin...