Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2

• Asıl Yazarlar: Daniela Vullo (Yazar), Ronny Lehneck (Yazar), Stefanie Pöggeler (Yazar), Claudiu T. Supuran (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The two β-carbonic anhydrases (CAs, EC 4.2.1.1) recently cloned and purified from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2, were investigated for their inhibition with a panel of 39 aromatic, heterocyclic, and aliphatic sulfonamides and one sulfamate, many of which are clinically use...