Influence of Genetic Admixture Components on CYP3A5*3 Allele-Associated Hypertension in Amerindian Populations From Northwest Mexico

• Main Authors: Carlos Galaviz-Hernández (Author), Blanca P. Lazalde-Ramos (Author), Ismael Lares-Assef (Author), Alejo Macías-Salas (Author), Margarita A. Ortega-Chavez (Author), Héctor Rangel-Villalobos (Author), Martha Sosa-Macías (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CYP3A5 metabolizes endogenous substrates and ~30% of prescription drugs. The CYP3A5 gene contains an active CYP3A5*1 allele, and a non-functional version, the CYP3A5*3 (rs776746), with consequences for drug therapeutic responses and side effects. Both CYP3A5*1 and *3 have been associated with hypert...