Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach

• Main Authors: Ronghua Bei (Author), Justin Thomas (Author), Shiven Kapur (Author), Mahlet Woldeyes (Author), Adam Rauk (Author), Jason Robarge (Author), Jiangyan Feng (Author), Kaoutar Abbou Oucherif (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTSubcutaneous injections are an increasingly prevalent route of administration for delivering biological therapies including monoclonal antibodies (mAbs). Compared with intravenous delivery, subcutaneous injections reduce administration costs, shorten the administration time, and are strongly...