Theoretical design for covering Engeletin with functionalized nanostructure-lipid carriers as neuroprotective agents against Huntington's disease via the nasal-brain route

• Main Authors: Smriti (Author), Madhav Singla (Author), Saurabh Gupta (Author), Omji Porwal (Author), Dalal Nasser Binjawhar (Author), Amany A. Sayed (Author), Pooja Mittal (Author), Fatma M. El-Demerdash (Author), Mohammad Algahtani (Author), Sachin Kumar Singh (Author), Kamal Dua (Author), Gaurav Gupta (Author), Puneet Bawa (Author), Ahmed E. Altyar (Author), Mohamed M. Abdel-Daim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington's disease (HD).Methods: We conducted a literature review of the pathophysiology of HD and the limitations of currently availa...