Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids

• Main Authors: Adriana Yamaguchi (Author), Christopher vanHoorebeke (Author), Benjamin E. Tourdot (Author), Steven C. Perry (Author), Grace Lee (Author), Nicole Rhoads (Author), Andrew Rickenberg (Author), Abigail R. Green (Author), James Sorrentino (Author), Jennifer Yeung (Author), J. Cody Freedman (Author), Theodore R. Holman (Author), Michael Holinstat (Author)
• Format: Book
• Published: Wiley, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15‐LOX‐derived metabolites (15‐oxylipins); however, whether 15‐LOX is in...