Development of Genetically Engineered Mice Lacking All Three Nitric Oxide Synthases

• Main Authors: Masato Tsutsui (Author), Hiroaki Shimokawa (Author), Tsuyoshi Morishita (Author), Yasuhide Nakashima (Author), Nobuyuki Yanagihara (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitric oxide (NO) is produced in almost all tissues and organs, exerting multiple biological actions under both physiological and pathological conditions. NO is synthesized by three different isoforms of NO synthase (NOS): neuronal, inducible, and endothelial NOSs. Due to the substantial compensator...