Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

• Main Authors: Carin K. Ingemarsdotter (Author), Sushmita Poddar (Author), Sarah Mercier (Author), Volker Patzel (Author), Andrew M.L. Lever (Author)
• 格式: 圖書
• 出版: Elsevier, 2017-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index. We used RNA trans-splicing to deliver the herpes simplex virus thymidine kinase-ganciclovir (HSV-tk/GCV) cell s...