Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells

• Hauptverfasser: Rubii Kondo (Verfasst von), Akari Deguchi (Verfasst von), Naoki Kawata (Verfasst von), Yoshiaki Suzuki (Verfasst von), Hisao Yamamura (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2022-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Activation of hepatic stellate cells (HSCs) causes hepatic fibrosis and results in chronic liver diseases. Although activated HSC functions are facilitated by an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt), the pathophysiological roles of ion channels are largely unknown. In the present...