Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy

• Main Authors: Peng He (Author), Shenglin Xu (Author), Zehao Guo (Author), Peng Yuan (Author), Yulei Liu (Author), Yu Chen (Author), Tiantian Zhang (Author), Yukang Que (Author), Yong Hu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The traditional systemic chemotherapy through intravenous infusion of doxorubicin (DOX) has many side effects. The aim of this study was to develop a PLGA-based DOX-loaded implant and to evaluate the efficacy and drug metabolism distribution of the implant in intratumoral chemotherapy for osteosarco...