Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity.

• Main Authors: Nailma S A Dos Santos (Author), Carlos F Estevez-Castro (Author), Juan P Macedo (Author), Daniela F Chame (Author), Thiago Castro-Gomes (Author), Mariana Santos-Cardoso (Author), Gabriela A Burle-Caldas (Author), Courtney N Covington (Author), Patrick G Steel (Author), Terry K Smith (Author), Paul W Denny (Author), Santuza M R Teixeira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a chronic illness for which no vaccines or effective...