From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity

• Auteurs principaux: Guido Gambara (Auteur), Manuela Gaebler (Auteur), Ulrich Keilholz (Auteur), Christian R. A. Regenbrecht (Auteur), Alessandra Silvestri (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different facets of ITH, from genomic to microenvironmental heterogeneity and the hierarc...