Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung

• Main Authors: Nataliia Kovalchuk (Author), Joseph L. Jilek (Author), Laura S. Van Winkle (Author), Nathan J. Cherrington (Author), Xinxin Ding (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paraquat (PQ) is an agrochemical known to cause pulmonary fibrosis. PQ-induced collagen deposition in the lung is thought to require enzymatic formation of PQ radicals, but the specific enzymes responsible for this bioactivation event in vivo have not been identified. We tested the hypothesis that l...