Burkholderia pseudomallei modulates host iron homeostasis to facilitate iron availability and intracellular survival.

• Main Authors: Imke H E Schmidt (Author), Claudia Gildhorn (Author), Martha A L Böning (Author), Vera A Kulow (Author), Ivo Steinmetz (Author), Antje Bast (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The control over iron homeostasis is critical in host-pathogen-interaction. Iron plays not only multiple roles for bacterial growth and pathogenicity, but also for modulation of innate immune responses. Hepcidin is a key regulator of host iron metabolism triggering degradation of the iron exporter f...